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Kamek is an evil Magikoopa wizard and an ally of Bowser in the Mario series. In SMG4's videos, he has appeared multiple times. First in SM64: Meet the Bowser, where he refers to Bowser as his senpai and states that he tries to get Bowser to notice him. He returns in SM64: Super Mario RUN RUN RUN!. In this episode, Mario stole Kamek's wand in hopes of make infinite spaghettis but Kamek is chasing him to reclaim his wand. Mario tries to use it but instead he turns Luigi into a cake, Daisy into a real daisy, Shy Guy into a toast and Toad into a teapot.
Mario sees Kamek so Mario tries to zap Kamek but Kamek dodges the attack, and it reflects from Toad as a teapot and hits Mario. Mario falls over and drops the wand and so Kamek picks it up and leaves. He teaches the Science class in High School Mario. He appears in SMG4: The Movie Audition where Kamek is in a Princess Peach costume and is being carried by Donkey Kong, who is playing King Kong, to the top of a tall tower.
He is used by Donkey Kong as a boomerang to hit Cuphead. In SM64: Mario gets a Nintendo Switch!, he makes a brief appearance when Mario dresses him up as Princess Peach as part of his cleaning chores. He appeared as a teacher yet again in SMG4: Mario University, this time teaching Computer Science. He reappears in SMG4: Detective Mario & Pikachu, where he attempts to comfort Bowser after the loss of the latter's statue, and once again dresses up as Princess Peach in order to get Bowser to notice him. He also appears in Super BACKWARDS Bros and SMG4: The Mario Café.