"President Toad has ordered to replace the castle with a grand casino with "dancing old people???" is what he said"
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Mario Cells are multiple tiny Marios that live in Mario to make him healthy.
They thought Luigi and Saiko were diseases, but after some evidence of them knowing Mario, they befriend them. They help lead Luigi and Saiko to the Virus.
The Mario Cells are majority inspired by white blood cells such as Lymphocytes and leukocytes, which are cells that are part of the human immune system that defends the body against diseases and foreign invaders.