Mario is under a spell where he can only run! How is he ever going to undo the curse?!
SMG4: Mario doing exercise?! Impossible!
Mario is running with Kamek's wand hoping to make infinite spaghetti but Kamek is chasing him for his wand. When Mario reaches the park, he tries to use it but instead he turns Luigi into a cake, Princess Daisy into a real daisy, Shy Guy into toast and Toad into a kettle. Mario sees Kamek so Mario tries to zap him but Kamek dodges the attack, reflects from Toad (kettle) and hits Mario. Mario falls over and drops the wand so Kamek picks it up and leaves.
Mario gets up but his legs start going like crazy and he runs off. He runs to SMG4 for help so he makes Mario trip. However, he kept moving on the floor so SMG4 took Mario to a doctor and being tied to a table by rope. Dr. Mario told Mario he's going to die from exhaustion but also prostate cancer so it will be a quick death. Mario ended up untied by the ropes and ran out of office. Believing he's going to become skinny, Mario notices Kamek in the distance and follows him to the city.
During Mario's chase after Kamek, he angers Dr. Eggman, Waluigi and Toast Guy who follow him. Kamek arrives at the Shopping Centre, parks his broom and enters the building. Mario follows Kamek to a aisle with cereal but Dr. Eggman appears and fires Pingases at him which crush him. Kamek leaves the aisle and goes to a food court to order food. Mario comes but Waluigi interrupts him and throws Bob-Ombs while singing "We are number one".
Waluigi chases Mario to the Restrooms and Mario locks himself in a stall. Toast Guy appears, breaking in with a tank. As Mario is running away from angry mobs, Kamek is heading to his broom. When he gets there, there's a parking ticket on it causing Kamek to get mad. Meanwhile. Mario flies off of a building. He gets up and sees Kamek around the street. Mario runs to Kamek only to get run over by RMKP car for jaywalking.
Kamek burns the parking ticket and takes off but Mario's not giving up. The latter found himself at Bowser's Castle but when he reached the entrance, the Guard Dog: Bootleg Sonic was released. Sonic knocks Mario who is holding the bridge to avoid falling in lava. Ugly Sonic points a gun at him but Mario throws a onion ring to the lava which Ugly Sonic mistakes as a real ring. The hedgehog jumps off to grab the onion ring, falling into the lava.
Meanwhile, Bowser is doing yoga while the radio is playing. Mario enters the same room and is surprised because of Bowser's actions. The Koopa King realizes Mario's here and punches the radio. Mario ignores him, jumps out the window and walks on the walls to Kamek while Bowser is upset. Kamek is watching TV when Mario breaks into his room. Mario demands Kamek to undo the curse but Kamek doesn't care.
Mario knocks over a nearby table which angers Kamek because he'll have to clean up. Kamek prepares to blast Mario but he starts to pick up speed and punches Kamek. Kamek drops his wand so Mario uses it to stop running. Although left with slightly crooked legs, Mario thanks Kamek to make him go through that adventure and runs out off the room.
- Heavy Weapons Guy dies in car crash.
- Waluigi throws the bomb at cashier.
- Bootleg Sonic falling into lava after Mario drops onion rings when Bootleg Sonic thinks onion rings is some golden rings.
- This episode ties into the new mobile app game Super Mario Run, as Luke's own attempts to promote it.
- This episode references Apu from The Simpsons.
- Kamek breaks the fourth wall by yelling "How dare you throw side characters at me!" after Mario throws Bob at him.
- Run Lola Run: This blooper is reference to this film.
- Super Mario Run: This blooper's name is a reference to the mobile app.
- 00:06 – Hit and Run; Ren & Stimpy
- 00:30 – Ghost Gulping; Paper Mario
- 00:43 – Arcanum-Brostep; Dubsteppie (uploaded by I’m A Doge)
- 00:56 – Remix 10; Rhythm Heaven Fever
- 01:12 – Overworld; Super Mario World
- 01:33 – Pokey’s House; Earthbound
- 01:57 – Battle Theme; Paper Mario: The Thousand Year Door
- 02:22 – A Thousand Miles; Vanessa Carlton
- 02:29 – Paper Mario 64 - Koopa Bros (remix); chao-guy (uploaded by shadowmario23)
- 02:45 – Mini-game Park; Mario Party 2
- 02:52 – Megalovania Elevator Music; EternalSushi
- 03:05 – The Blue Skies Yonder; Mario Party 2
- 03:34 – Assault Theme; Metal Slug 3
- 03:40 – I Need A Hero; Jennifer Saunders
- 03:44 – We Are Number One (Waluigi); The Tveit
- 04:03 – Yakety Sax; Boots Randolph
- 04:11 – Groose’s Theme; Legend of Zelda: Skyward Sword
- 04:26 – Into The Cosmos; Metal Slug 3
- 04:33 – F**k the Police; Ice Cube
- 04:38 – Mario Party 1 & 2 – Bowser’s Theme (Remix); Qumu
- 04:52 – Green Trill Zone; Cyranek
- 05:15 – O Fortuna (Carmina Burana); Carl Orff
- 05:27 – Ultimate; Denzel Curry
- 05:33 – Give It All You’ve Got; Spongebob
- 05:51 – Woody Woods; Mario Party 1
- 06:14 – Brilliant Thief (Remix); DjtheSdotcom
- 06:27 – Asphyxiation; Left 4 Dead 2
- 07:06 – Ending Theme; Super Mario World