SMG4: Lord Of The Memes is the sixth episode of Season 10 and the five hundred and fifty-ninth overall to be uploaded by SMG4.
This episode was aired on February 22, 2020.
In his never-ending quest to reach Meme lord status, a sleep-deprived SMG4 managed to create the Ultimate Meme, storing it in a USB Flash Drive, and planned to use it to control the Internet. Before he could unleash its power, Bob and Mario interrupted him (they apparently wanted to throw rocks at elderly people) with Bob taking the USB to investigate. Realizing the meme was too powerful for any one person, Bob sent Mario along with Luigi and Fishy Boopkins to destroy the meme in the sweaty ball pit at Dashcon, believing Mario would be too stupid to be tempted by the meme. SMG4 then summoned the Mario Head and several Memewraiths (clones of Kermit wearing robes) to get the meme back.
The Mario Brothers, Bob, and Boopkins began their journey, narrowly avoiding the Memewraiths. At the so-called Mall of Moria (parodying the Mines of Moria), Bob fell into Don Resetti's tank of bleach (which bleached his robe white) in a suicidal attempt to divert the Memewraiths while Boopkins accidentally caught a glimpse of the meme, causing him to become obsessed with it. As a result, he tried many failed attempts to get the Mario Bros. killed and take the meme back, which only got them further to their objective. Eventually, the party made it to Dashcon. Evading the Memewraiths with the help of the con attendees, Mario prepared to destroy the meme, but Boopkins attempted to take it for himself. Luigi ended up being the one to destroy the meme by knocking Boopkins into the ball pit with it. Though destroyed, Boopkins's knowledge of the meme (he reported it had Pingas music in it) tempted Bob (now called "Bob the White") into seeing if another could be made.