The actual video starts with Fishy Boopkins sitting on a bench near Peach's castle, completely depressed after the events of The Mario Concert due to ruining Bob's concert. SMG4 was walking happily to the castle until he noticed Boopkins, who refused to talk about his depression. Attempting another tactic, SMG4 offered to watch anime with him, but Boopkins refused, causing the YouTuber to get shocked as his friend would usually never say "no" to anime and walked backwards to the castle.
Inside the castle, Mario and the gang were playing Super Smash each other in the ass bros Ultimate until SMG4 entered, telling everyone about Boopkins' plight. As a result, the gang started arguing over how to make Boopkins better, which culminated into a fight. SMG4 angrily broke up the fight and told everyone to do it their own way. They accepted, starting with Mario.
Mario's attempt
Mario turned himself into his doctor version and used his bad doctor talent to cure him. He kicked Boopkins into Peach's Castle and asked him how he felt like, but when Fishy Boopkins refused to tell him about it, Mario diagnosed him with AIDS, before taking out some surgery equipment and telling him that he needed to open his body, saying: "Give me that butt!" Boopkins naturally ran away, going past Peach Toadstool. Long after Boopkins was gone, Mario opened the door still saying: "Give me that butt!" Of course, since Boopkins was gone, Peach assumed that statement was for her, getting her offended. Mario tried to explain but was too late as Peach slapped him into the Wet-Dry World painting.
Luigi's attempt
As Boopkins was trying to escape the castle, Luigi disguised Toad as Bob so that Toad could make Boopkins feel better by causing the latter to think that Bob had accepted his apology. At first, it worked until Boopkins hugged Toad so strong that it killed him from suffocation. Upon seeing his plan backfire, Luigi then revealed that the "dead" Bob was just Toad to not make Boopkins feel responsible for Bob's murder. After that, he brought the corpse back to Dr. Mario, who escaped the Wet-Dry World painting from earlier.
SMG4's attempt
SMG4 appeared shortly after Luigi returned the dead Toad and took Boopkins into his room to show him some memes. He attempted to have Boopkins watch one of his videos and even took out a couple of memes (a dabbing Robloxian, a Dr. Eggman head, and Baldi) from his chest full of memes to try to make the Spike laugh, but they at most only scared Boopkins instead of injecting some humor into him. Realizing that none of the memes were working, SMG4 searched his chest until he found the most cancerous memes that existed.
Meanwhile, Bowser entered the room with rocks for Boopkins to eat and was unaware of what SMG4 unleashed into the room beforehand. The Koopa King was taken by the memes storm and SMG4 closed the chest on them without knowing that Bowser was caught in the memes. He then discovered that Boopkins had jumped through the window.
Shroomy's attempt
Shroomy appeared where Boopkins landed in the garden, after escaping from SMG4's cancerous meme storm. Now with his enhanced powers as a robot, he took Boopkins and flew around the world with the Spike in his hands, until his subject said that he wanted to be put back down on the ground. However, Shroomy decided to land back at the castle with super speed, crushing Boopkins in the process.
Tari, Meggy & Saiko's attempt
Later, while Boopkins was watching an advertisement for "Buy-A-Bob" from War of the Fat Italians 2017, he was caught on a fish hook and pulled out of the water by Saiko. Once they got Boopkins out of the water, Saiko Bichitaru took him to one of Bob's concerts with Tari and Meggy. However, this only caused Boopkins to cry and run out of the stadium while Bob was performing, now more popular than ever during his rap career. Still wanting to stay and watch Bob, Saiko told Tari and Meggy to go find Boopkins and continued to cheer him up without her.
Tari and Meggy subsequently found Boopkins huddled in an alley, where the two girls decided to go with their "last resort" to cheer him up. The "last resort" happened to be taking Boopkins to a "sexy maid cafe," even though Meggy hated it (considering how she was not a fan of anime). Fortunately, the idea of going to the cafe made Boopkins very happy, at least for the time being. But Meggy, upset about eating at the cafe, mentioned that she might need a lot of therapy after her visit, obviously regretting her and Tari's decision from earlier. The video then ends with Meggy fainting upon seeing Heavy dressed as a maid and saying that he was a "pretty princess."
SMG4: War On Smash Bros Ultimate: Shroomy still being a robot and everyone playing Super Smash each other in the ass Brothers Ultimate at the start.
The Waluigi Arc: One of the memes SMG4 takes out of his chest is Waluigi's staff.
SMG4: War of the Fat Italians 2017: The commercial used in SMG4's round of "Who can make BOB more popular?" is on the TV in Boopkins' place.
SMG4: Mario waits for pizza: Meggy's hatred of anime is shown again when she was taken to an anime-related restaurant. She said she needed a therapist.
Trivia
In this episode it's revealed that Saiko now loves Bob as she ran to him hinting that she is one of his fans.
Out of all the characters. Tari and Meggy are the only ones who were able to cheer Fishy Boopkins up.
