Mario and SMG4 use an ultra-powered cannon, and find themselves in a new place. The two explore the area to try to get back home.
The blooper starts with Lakitu rigging a cannon to make it 100x more powerful (which Mario takes all the credit for), while SMG4 watches. Lakitu finishes, and Mario tests the cannon first. It sends him flying all the way to a forest village. SMG4 follows afterward. The two decide to ask around and find out where they are, and then they meet an elf girl. The girl tells them that there is a sacred tree that will decide their fates, whether they live or die.
Mario and SMG4 go to see the tree, and it turns out to be the same tree Mario burned down in Clone O' Mario.￼ The tree recongizes this, and decides to not grant whatever wish they were wanting. Mario and SMG4 beg, and the tree says that if they wish to go home, they need to find a potion that will cure the tree's curse.
The duo heads back to the village to try to find such a potion, but to no avail. They meet a guy searching for weed, Mario burns down a private club, and they meet another guy humping a rock. Mario and SMG4 decide that if they wish to continue their search, they need to leave the village. After killing another elf, they move onward.
The two find themselves at a castle town, where they find a shop. Inside, they meet a gay cashier and an old hobo. After Mario sets the cashier on fire, the hobo tells them of an ancient potion that could cure any curse, and that it is somewhere in this land. Sadly, the hobo doesn't actually know where the potion is.
The heroes move on to another town, where they continue their search. They meet a clueless guard, accidently walk into the gay cashier's shop again, Mario makes a guy angry and gets launched across the town, and SMG4 meets a man under a spider curse, who says he knows where a cure for curses is. Unfortunately, Mario decides to kill the spider, and then blows the building up.
Mario and SMG4 head back to the castle town, where Mario reveals that he received a potion two hours prior. He obtained it from a creepy looking guy who says the potion can cure anything. The duo head back to the tree, to whom they use the potion on. The tree says life is coming back to it, only to end up dieing. SMG4 reads the potion's label, and it turns out that the potion is actually tree killer. Mario has an angry fit, and the blooper ends.