When Luigi catches a rare disease, Mario has to find the cure for him.
Mario is trying to find Luigi because he owes Mario ten dollars, so he looks everywhere (lifting King Bob-omb and throw him, grabbing on the owl, top of the castle, in the aquarium, underneath Bowser, and glitching on Peach's stain glass window) till he hears Luigi calls for help which was coming from Peach's room. Mario goes in the room to see him and looks disgusted comes back out puking.
He goes to Toad saying "umm Toad, you might want to see this...". Toad goes into the room finds Luigi with missing limbs and a white head. Luigi was speaking in gibberish and Mario couldn't get him to speak in English (text), and he calls Dr.Mario. Dr. Mario examines Luigi and says that has Weegee Disease, a rare type of disease. When Mario heard that it was rare he didn't care about it until Luigi's gibberish was starting to annoy him. Mario said, "We got to cure him." Dr. Mario explains that there was no cure in existence and goes back in the ambulance to steal some drugs. Mario starts to panic and decides to search for a professional wizard about this cure until he eventually finds one.
Merlon tells Mario that he knows a cure, but the wizard needs a rare herb that is found deep in a forest (which one?). Mario then travels to different woods. He gets lost in one of them and ends up burning the place down. After giving up, he goes back in the castle to see if Luigi is back to normal, and gets a weird dance which made him puke again. Mario then continues to look for the herb only to get annoyed by natives. Outside the castle, the fat plumber sees a weird plant growing on top of the castle then decides to go for it. While doing that, Doopliss (some random character made by 12-year-old SMG4) stole the herb and Mario tries to get it back from him but gets blown away back to Merlon's place. The wizard asks for the herb and the plumber explains what happened. Merlon notices a 1up mushroom from his pocket and uses it to make the cure.
Mario gets the cure and heads back to Luigi to give him it. Luigi drinks the potion and explodes. Mario starts to sob (only for Luigi owing him ten dollars) while Luigi came into the room causing Mario to be surprised. Luigi explains that the Luigi who exploded was a robot he programmed which made everyone thought he was sick (including the viewers) and also states that Dr. Mario is a fake doctor and more of a terrorist then he goes ahead to watch sm64 bloopers. Mario leaves the room for the third puking which ends the Blooper. Mario: he still owes me 10 dollars